IGF DES, Lets talk about it, what it is and what it may do for your research subjects. First lets touch on igf, what it is and what it does.
IGF is Insulin-Like Growth Factor. It is very similar to insulin in structure but has its own receptor sites it acts upon. It is crucial to cell proliferation and the prevention of cell death significantly in muscle tissue. It is naturally produced in the liver of research subjects and is primarily dependent upon the levels of growth hormone. Meaning the higher levels of Growth Hormone, the higher IGF levels that will be present. This is particularly of interest to us in our research. Many researchers believe that one of the primary benefits of Growth Hormone is in fact, increased IGF and its effects.
IGF is also responsible for many other effects in the body, however IGF DES may not apply to these things. IGF DES has a very short half-life. While other forms of IGF have a longer half-life , DES has a half-life of just 20-30 minutes. What does this mean? Well it mean that other forms of IGF , due to their longer half-lives, have the ability to act on IGF receptors systemically, whereas IGF DES will act on receptors locally, primarily at the site of administration. It also bears mention that IGF DES is significantly more potent than other forms of IGF, as much as 10x more powerful than say IGF 1.
Think about what the last 2 sentences may mean in our research. A substance that acts locally and induces muscle cell hyperplasia, this means an increase in the number of muscle cells. Also a substance or form of IGF 10x more potent then endogenous IGF1! One can easily see where IGF DES may be beneficial in our research subjects as far as increasing the number of muscle cells in area that may have reduced muscle size. It could be used to “even out” muscle distribution, ie: lagging muscle groups in research subjects. It could also be of use to induce muscle growth in said subjects across the board depending on the sites of administration.
There are a few interesting things that bear mentioning when it comes to researching with IGF DES. It appears that in order for it to be effective their needs to be muscle activity at the site of injection. In fact, not just muscle activity, but muscle activity to the point of lactic acid being present. This is not often mentioned but has been shown to be the case.
So what does this all mean in our research? Well it mean that IGF DES can effectively increase the number of muscle cells at the site of administration, when administered to muscle that has undergone strenuous activity to the point of lactic acid being present. This is more than exciting for our research purposes.
Another thing that bears mention when it comes to IGF, IGF is a peptide that needs to be recombinant DNA synthesized. This is an expensive process. If you see IGF or IGF DES that is inexpensive then it is a good possibility that this was NOT the process used to synthesize the peptide. If this is the case, the peptide is not biologically active at all. All our peptides that require Recombinant DNA synthesis to be biologically active are manufactured in that exact fashion. This cannot be emphasized enough. IGF priced at too good to be true prices, is no good for you research purposes.
To wrap it up, this was designed to be a simple straightforward explanation of IGF Des, what it is, what it does, and how it can be effectively incorporated into your research. As you can see if you use top quality IGF DES, that is recombianantly synthesized such as ours is, you have the ability to induce localized muscle growth in your research subjects as a result of muscle cell hyperplasia provided muscle activity to the point of lactic acid being present. As you can see this is a significant and desirable effect in our research circles. I hope this write up cleared up some things about IGF and specifically this form of IGF. Best of luck in your research!
More Info and purchase top quality IGF DES HERE.
Refs:
*Woods AG, Guthrie KM, Kurlawalla MA, Gall CM (1998). "Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats". Neuroscience 83 (3): 663–8. doi:10.1016/S0306-4522(97)00539-3. PMID 9483550
*A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo
A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo
Thea Shavlakadze1,*, Jinfen Chai1, Kirsten Maley1, Greg Cozens1, Griffin Grounds1, Nadine Winn2, Nadia Rosenthal2 and Miranda D. Grounds1
*J Cell Physiol. 1999 Feb;178(2):227-34.
Effect of insulin-like growth factor (IGF)-I and Des (1-3) IGF-I on the level of IGF binding protein-3 and IGF binding protein-3 mRNA in cultured porcine embryonic muscle cells.
Yang F1, Johnson BJ, White ME, Hathaway MR, Dayton WR.
IGF is Insulin-Like Growth Factor. It is very similar to insulin in structure but has its own receptor sites it acts upon. It is crucial to cell proliferation and the prevention of cell death significantly in muscle tissue. It is naturally produced in the liver of research subjects and is primarily dependent upon the levels of growth hormone. Meaning the higher levels of Growth Hormone, the higher IGF levels that will be present. This is particularly of interest to us in our research. Many researchers believe that one of the primary benefits of Growth Hormone is in fact, increased IGF and its effects.
IGF is also responsible for many other effects in the body, however IGF DES may not apply to these things. IGF DES has a very short half-life. While other forms of IGF have a longer half-life , DES has a half-life of just 20-30 minutes. What does this mean? Well it mean that other forms of IGF , due to their longer half-lives, have the ability to act on IGF receptors systemically, whereas IGF DES will act on receptors locally, primarily at the site of administration. It also bears mention that IGF DES is significantly more potent than other forms of IGF, as much as 10x more powerful than say IGF 1.
Think about what the last 2 sentences may mean in our research. A substance that acts locally and induces muscle cell hyperplasia, this means an increase in the number of muscle cells. Also a substance or form of IGF 10x more potent then endogenous IGF1! One can easily see where IGF DES may be beneficial in our research subjects as far as increasing the number of muscle cells in area that may have reduced muscle size. It could be used to “even out” muscle distribution, ie: lagging muscle groups in research subjects. It could also be of use to induce muscle growth in said subjects across the board depending on the sites of administration.
There are a few interesting things that bear mentioning when it comes to researching with IGF DES. It appears that in order for it to be effective their needs to be muscle activity at the site of injection. In fact, not just muscle activity, but muscle activity to the point of lactic acid being present. This is not often mentioned but has been shown to be the case.
So what does this all mean in our research? Well it mean that IGF DES can effectively increase the number of muscle cells at the site of administration, when administered to muscle that has undergone strenuous activity to the point of lactic acid being present. This is more than exciting for our research purposes.
Another thing that bears mention when it comes to IGF, IGF is a peptide that needs to be recombinant DNA synthesized. This is an expensive process. If you see IGF or IGF DES that is inexpensive then it is a good possibility that this was NOT the process used to synthesize the peptide. If this is the case, the peptide is not biologically active at all. All our peptides that require Recombinant DNA synthesis to be biologically active are manufactured in that exact fashion. This cannot be emphasized enough. IGF priced at too good to be true prices, is no good for you research purposes.
To wrap it up, this was designed to be a simple straightforward explanation of IGF Des, what it is, what it does, and how it can be effectively incorporated into your research. As you can see if you use top quality IGF DES, that is recombianantly synthesized such as ours is, you have the ability to induce localized muscle growth in your research subjects as a result of muscle cell hyperplasia provided muscle activity to the point of lactic acid being present. As you can see this is a significant and desirable effect in our research circles. I hope this write up cleared up some things about IGF and specifically this form of IGF. Best of luck in your research!
More Info and purchase top quality IGF DES HERE.
Refs:
*Woods AG, Guthrie KM, Kurlawalla MA, Gall CM (1998). "Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats". Neuroscience 83 (3): 663–8. doi:10.1016/S0306-4522(97)00539-3. PMID 9483550
*A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo
A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo
Thea Shavlakadze1,*, Jinfen Chai1, Kirsten Maley1, Greg Cozens1, Griffin Grounds1, Nadine Winn2, Nadia Rosenthal2 and Miranda D. Grounds1
*J Cell Physiol. 1999 Feb;178(2):227-34.
Effect of insulin-like growth factor (IGF)-I and Des (1-3) IGF-I on the level of IGF binding protein-3 and IGF binding protein-3 mRNA in cultured porcine embryonic muscle cells.
Yang F1, Johnson BJ, White ME, Hathaway MR, Dayton WR.
IGF DES- The Key to Localized Growth?
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